From the 8 Freeway and the 5 Freeway:
Take 8 West to the 5 South. Exit Sassafrass/San Diego Airport exit. Turn Right onto Sassafrass from the exit and take it to Paific Coast Highway. Turn Left on PCH and take it until you come to Laurel St. onto which you will turn Right. Stay to the Right as Lauel turns into N. Harbor Drive.  Take N. Harbor Drive until you come to Harbor Island Drive (directly across from Terminal 1). Turn left onto Harbor Island Drive. When you reach the water, turn Right. The Boat House is on the right side of the road (3/4 mile down) right past the Hilton Hotel.

From the 163 Freeway:
Take 163 south to 5 north. Exit Hawthorn/San Diego Airport exit. Take Hawthorn to N. Harbor Drive and turn Right onto N. Harbor Dive. Take N. Harbor Drive until you come to Harbor Island Drive (directly across from Terminal 1). Turn left onto Harbor Island Drive (stop light at Sheraton Hotel). When you reach the water, turn Right. The Boat House is on the right side of the road (3/4 mile down) right past the Hilton Hotel.